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The heart used in the transplant came from a pig with several genetic modifications, including some to knock out genes that trigger the human immune system. Credit: University of Maryland School of Medicine
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This medical news might trigger some communities out there, but trust me and read this through.
First of all, pig heart? For real?
The first person to receive a heart transplant from a genetically modified pig is recovering well following the treatment, which took place last week in Baltimore, Maryland.
Transplant surgeons believe that the advancement will allow them to provide more humans with animal organs, but various ethical and technological challenges may come to mingle along the journey.
"This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis. There are simply not enough donor human hearts available to meet the long list of potential recipients," Dr. Bartley Griffith, who surgically transplanted the pig heart into the patient, said in a statement.
&ldquo;We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future,&rdquo; Griffith added.
Why Did You Agree For A Pig&rsquo;s Heart Inside Your Chest?
It was a life and death option for 57-year-old David Bennett.
&ldquo;It was either die or do this transplant. I want to live. I know it&rsquo;s a shot in the dark, but it&rsquo;s my last choice,&rdquo; Bennett said a day before his surgery, according to a statement released by the university.
Bennett had been on cardiac support for almost two months and couldn&rsquo;t receive a mechanical heart pump because of an irregular heartbeat.
Neither could he receive a human transplant, because he had a history of not complying with doctors&rsquo; treatment instructions. Given that he otherwise faced certain death, the researchers got permission from the FDA to give Bennett a pig heart.
The Procedure
Of course, it was nothing like, "Hey, how about a surgery with a pig's heart?" and Bennett like, "Yeah dude, why not."
<img style="display: block; margin-left: auto; margin-right: auto;" src="https://cdn1.myc.com.my/image/upload/v1642411770/unsigned/i0iugqaa8yquv4vuupmh.gif" alt="" width="480" height="270" />
The institution gained emergency approval from the US Food and Drug Administration on New Year's Eve to proceed with the experimental procedure under its compassionate use programme.
According to Al Jazeera news, "The FDA used our data and data on the experimental pig to authorise the transplant in an end-stage heart disease patient who had no other treatment options," said Dr. Muhammad Mohiuddin, who heads the University's programme on xenotransplantation &ndash; transplanting animal organs into humans.
There are about 110,000 Americans who are currently on the waiting list for an organ transplant, and more than 6,000 patients lose their life every year before getting one, as mentioned by <a href="https://www.organdonor.gov/">organdonor.gov</a>.
Revivicor, a regenerative medicine company located in Virginia, equipped Bennett with his genetically engineered pig heart. The transplant team extracted the pig's heart the morning of the surgery and placed it in a special device to keep it functioning until the actual&nbsp;surgery for Bennett.
In the heart implanted in Bennett, three genes previously linked with organ rejection were &ldquo;knocked out&rdquo; of the donor pig, and six human genes linked with immune acceptance were inserted into the pig genome.
To avoid unnecessary development of the pig heart tissue, researchers also removed a pig gene.
The research was partially financed by a $15.7 million research grant to test Revivicor's genetically modified pig hearts in baboon studies.
Bennett was given an experimental anti-rejection medication concerning the genetic alterations to the pig heart.
<img src="https://cdn1.myc.com.my/image/upload/v1642411796/unsigned/pdvq9z1nyx5p6zx1otxz.png" /> David Bennett (third left) poses for a picture with his family. Doctors transplanted a pig heart into Bennett in a last-ditch effort to save his life and said he was doing well three days after the surgery [Byron Dillard via AP Photo]
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What do you think about this ultimate finding on human and the use of a pig's heart? Share us your thoughts!
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*Sources: Visual and Reference Credits to Social Media, Al Jazeera, &amp; various cross references for context.
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Surgeons hope genetic modifications will help the patient's body accept the organ and that pig organ could help alleviate shortages of donor organs.

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US Man Survives After Having Heart Transplant From A Pig!

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US Man Survives After Having Heart Transplant From A Pig!

Surgeons hope genetic modifications will help the patient's body accept the organ and that pig organ could help alleviate shortages of donor organs.

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